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ISEI has created an investigative, active learning environment to facilitate student-faculty collaborative research in the sciences. The data collected in this environment form a long-term, multi-disciplinary Natural History Data Repository (NHDR). The NHDR focuses on the St. Lawrence River Valley and Adirondack Highlands and contains both spatial and non-spatial data. Additional data in the repository include historical data, museum and herbarium records, and data from the ISEI weather stations. The NHDR is an information resource for both faculty and student research and will serve as a tool for teaching and demonstrating the complex interdependence of elements in the natural world.